CURRICULUM VITAE - VANNA MICHELI


Education and training

Degree in Biological Sciences at the University of Siena in 1971: full marks with honours (110/110 e lode), after a two-year training developing researches for the degree thesis on the ultrastructure and biochemical characteristics of insect spermatozoa (Tenebrio molitor L.).
Two-year fellowship (1972-1974) for training in research and teaching at the Istituto di Chimica Biologica of the University of Siena (Faculty of Pharmacy).
Research contract  for four-year (1975-1979) in the same institution.
British Council awards in 1987 and 1990 to develop researches and achieve expertise in the pathological aspects of nucleotide metabolism (purines, pyrimidines and pyridines) in genetically determined disorders at the Guy’s Hospital, University of London, UK .
ESSPPMM aword to attend the Symposium on Purines and Pyrimidines in man (Hakone, Japan, 1988)

Employment and research experience

Vanna Micheli developed her research and teaching activity since 1972 in the University of Siena, at first in the Istituto di Chimica Biologica, and then in the Dipartimento di Biologia Molecolare.
Her researches were mainly concerned with nucleotide metabolism (purines, pyrimidines and pyridines and their metabolic connections) and with oxido-reductive mechanisms in different biological sources: experimental animals, circulating human blood cells and cell cultures. Studies on human metabolism particularly focussed on physiopathological states: genetically determined disorders, aging, tumours. In the meantime she also studieded the metabolic and functional characteristics of human erythrocytes with particular interest in the nucleotide pattern and metabolism in different phyisopathologic conditions. The acquired expertise in these fields yielded in many collaborations with researchers in different clinical areas and in the development of several analytical methods with diagnostic significance. Recent studies evidenced altered nucleotide pattern and enzyme activities in different human cell types bearing pathological mutations and in experimental models of genetically determined disorders. She spent particular efforts in the study of HPRT deficiency and related Lesch-Nyhan syndrome; studies were performed in erythrocytes, lymphocytes and fibroblasts from patients. She developed researches at the Guy’s Hospital, University of London, collaborating with the Purine Laboratory directed by Dr. H.A. Simmonds (British Council awards in 1987 and 1990). She took part in research collaborations with italian and european groups, as a member of the Scientific Committee (from 1993 up to now) and of the Board (from 1993 to 2000) of the European Society for the study of Purine and Pyrimidine Metabolism in Man, and as the Italian contractor in an European project ( Biomed contract 1998-2000). She is author of 98 papers published on international journals, and of 172 abstracts of presentations at national and international scientific meetings.

Vanna Micheli obtained a permanent position as University Researcher (Ricercatore Universitario) at the University of Siena in 1980.. She was first assigned the Faculty of Pharmacy and later she moved to the Faculty of Medicine and Surgery.
She won a national competition for the position of Associated Professor at the University of Siena (subject area BIO/10, Biochemistry) in 2001